Date

Thursday 28 May 2026

Time

16:00 - 16:30

Location

online

Supervisor

Sylvestre Bonnet

2nd reviewer

Sander van Kasteren

Jury

Roxanne Kieltyka

Cyclometalated Pd(II) photosensitizer (PS), PdL1, was reported as a promising green light PDT agent with self-assembling behavior. To further enhance the PDT performance of PdL1, this study explored geometric modification of the PdL1 and evaluated its photodynamic activity under blue and green light. Accordingly, two geometric isomers of PdL1, PdL2 and PdL3, were investigated. PdL1 showed a high photoindex (PI) (10) at blue light (8 J cm-2) and the highest PI (35) at green light (26 J cm-2), suggesting strong PDT effect under both green and blue light. However, the PI of PdL2 close to 1-2 at all the light doses of blue and green light, with a weak PDT ability comparing with PdL1. The previous study of PdL3 suggested that the highest PI 66 at blue light (8 J cm-2) and the highest PI 5 at green light (26 J cm-2). Thus, PdL3 is a better blue light PDT PS than as a green light PS. In addition, a known emissive cyclometalated Pt complexes [PtMeL]OAc ([PtL4]+), with similar ligand structure to PdL1, were introduced to enhance the cellular imaging capability of the PdL1 system in this study. A series of PdL1:[PtL4]+ mixtures with varying molar ratios was prepared to evaluate their cellular imaging and PDT performance. At PdL1: [PtL4]+ = 1:9, the mixed system exhibited a dominant emission band at 663–738 nm that localized around the cell nuclei, indicating efficient intracellular imaging. Under green light irradiation at a total metal concentration of 1 μM, mixtures with PdL1:[PtL4]+ ratios between 1:9 and 7:3 displayed dark-to-light cytotoxicity ratios (D/L = 1.1–25; D/L defined as cell viability in the dark divided by cell viability under light) than [PtL4]+ alone (D/L = 1.1). Notably, the 1:9 mixture showed the highest D/L ratio than PdL1 alone, suggesting that [PtL4]+ exerts a synergistic effect on the green light PDT activity of the mixture.

Thesis talk can be attended through link. Make a screenshot to prove your attendance.

https://eur03.safelinks.protection.outlook.com/ap/t-59584e83/?url=https%...